do they work in the middle of a marathon?

good question, i have never run a marathon so i cannot really say. i do play beach volleyball for about 6 to 7 hours on sunday through the months of good weather, running and diving on the court does wear on a person and cramps usually occur at the end of the day. i usually take the cramp tablets approx. a half hour prior to ending my day and heading for the parking lot which also entails climging a trail up a hill about 600 ft. up to the parking area. these tablets work great, without the use of the tablet, i would start to have severe leg cramps about 200 ft after starting the climb, since using the tablet i have no cramping all the way to the car. it may not be the same as running a marathon, but running in sand for six hours is a great workout. good luck, well worth the try.

Is this a quick responds under the tongue?

They dissolve quickly under the tongue and generally the cramps are relieved within a minute or two.

Do these work for cramps/muscle spasms in other parts of body such as hands, chest, stomach, arms etc or only for feet and legs???

Thank you for your question. Hyland’s Leg Cramps are labeled specifically for cramps that occur in the calves, feet and legs. They are not labeled for the treatment of cramps/muscle spasms in other parts of the body such as hands, chest, stomach and arms. Hyland’s does not offer a consumer product for treatment of hand and arm cramps. If you have any additional questions, please do not hesitate to contact us directly, our Customer Service team can be reached many ways: online as you have, at info@hylands.com or by phone at 800.624.9659 (M-Th 8:30am-7pm; F 8:30am-5:30pm Eastern Time). We also have Product Information specialists that can answer more in-depth questions. Hyland’s Support Team

Does this product actually have quinine in it?

From their web site:Hyland's Leg Cramps contains the homeopathic medicine Cinchona Officinalis HPUS, which is made from the bark of the Cinchona tree, commonly called "Quinine Bark". This bark is the source ingredient for quinine as well as the source of the ingredient in our homeopathic medicine.

Weight	1.58 Pounds
Units	100.0 Count
Serving Recommendation	Hyland's Leg Cramps pills can be taken at the first indication of a muscle cramp to relieve pain and cramping.
Brand	Hyland's
Format	Tablet
Age Range Description	Adult

Hyland'sHomeopathic Leg Cramps, 100 tabs (Pack of 1)

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