---
product_id: 257288700
title: "THORNE Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules"
brand: "thorne"
price: "KD 28.93"
currency: KWD
in_stock: true
reviews_count: 5
category: "Thorne"
url: https://www.desertcart.com.kw/products/257288700-thorne-methyl-guard-methylation-support-supplement-with-folate-and-vitamin
store_origin: KW
region: Kuwait
---

# Active methylated B12 & folate Free from gluten, soy, dairy & major allergens 180 capsules of methylation power THORNE Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules

**Brand:** thorne
**Price:** KD 28.93
**Availability:** ✅ In Stock

## Summary

> 🧠 Elevate your wellness game with THORNE Methyl-Guard — because your genes deserve the best!

## Quick Answers

- **What is this?** THORNE Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules by thorne
- **How much does it cost?** KD 28.93 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.com.kw](https://www.desertcart.com.kw/products/257288700-thorne-methyl-guard-methylation-support-supplement-with-folate-and-vitamin)

## Best For

- thorne enthusiasts

## Why This Product

- Trusted thorne brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Pure & Allergen-Free Formula:** Crafted without gluten, soy, dairy, shellfish, or major allergens—clean nutrition you can trust.
- • **Precision Methylation Support:** Harness the power of 5-MTHF and methylcobalamin for optimal gene expression and energy metabolism.
- • **Homocysteine Metabolism Booster:** Promotes healthy homocysteine levels to reduce cardiovascular risks and enhance wellness.
- • **Trusted by Thousands with MTHFR:** Clinically favored by users managing MTHFR gene mutations for improved cycle regularity and reduced cramps.
- • **Comprehensive Cardiovascular & Cognitive Care:** Supports heart, blood vessels, brain, nerves, and bone health in one potent formula.

## Overview

THORNE Methyl-Guard delivers 180 capsules of advanced methylation support featuring active methylated folate (5-MTHF) and vitamin B12 (methylcobalamin). Designed to promote healthy homocysteine metabolism and support cardiovascular, neurological, and bone health, this allergen-free supplement is a top choice for adults seeking clean, effective methylation aid, especially those with MTHFR gene concerns.

## Description

THORNE Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules : desertcart.ae: Automotive

Review: Excellent product for MTHFR genetic disorder
Review: High quality B complex! Helpful for MTHFR gene mutation. I have been using them for about six months now and notice a huge difference in my cycle regularity, as it has very high amounts of B6 and a methylated form, I’m convinced is due to this product. My menstrual cramps have all but almost completely disappeared, which is absolutely amazing considering I have struggled with that since my teens could not recommend this more, especially for women struggling with similar issues.

## Features

- Methylation: Support for healthy methylation*
- Multiple Functions: Support for heart, blood vessel, brain, nerve, and bone health*
- Homocysteine: Promotes homocysteine metabolism*
- Active Bs: Contains the active, methylated forms of folate and vitamin B12 (5-MTHF and methylcobalamin)
- Free From: Every Thorne product is made with the purest possible ingredients - without gluten or other major allergens (eggs, tree nuts, peanuts) This product also contains no soy, dairy, shellfish, or fish

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0012FJVA2 |
| ASIN  | B0012FJVA2 |
| Age Range Description | Adult |
| Allergen Information | Shellfish Free |
| Best Sellers Rank | #2,368 in Health ( See Top 100 in Health ) #85 in Multiple Vitamin-Mineral Combination Supplements |
| Brand | THORNE |
| Customer Reviews | 4.7 4.7 out of 5 stars (2,620) |
| Customer reviews | 4.7 4.7 out of 5 stars (2,620) |
| Date First Available | 9 August 2012 |
| Format | Capsule |
| Is Discontinued By Manufacturer  | No |
| Manufacturer  | Thorne Research |
| Manufacturer reference  | SF787-R |
| Product Dimensions  | 7.34 x 7.34 x 13.26 cm; 0.18 g |
| Units | 180 Count |
| Weight | 0.45 Pounds |

## Product Details

- **Brand:** THORNE
- **Diet type:** Gluten Free
- **Flavour:** Unflavored
- **Item form:** Capsule
- **Primary supplement type:** Vitamin B and Folate

## Images

![THORNE Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules - Image 1](https://m.media-amazon.com/images/I/61Cgh5TOkrL.jpg)

## Questions & Answers

**Q: Is there a scientific study that I can read that will back up these claims?**
A: Absolutely, there are studies!  There are enough that I need to ask you to be more precise in what you want to know.  Which ingredient are you interested in, for what population, and concerning what symptoms?  Your local library may be able to help you access research databases that will allow you to search to your heart's content.  State libraries may be used by any taxpayer, and some medical schools will allow community members a day pass.  Here is a little taste, notice how long this research has been going on: 1) Weisberg, I., Tran, P., Christensen, B., Sibani, S., & Rozen, R. (1998). A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Molecular genetics and metabolism, 64(3), 169-172.2) Grandone, E., Margaglione, M., Colaizzo, D., Cappucci, G., Paladini, D., Martinelli, P., ... & Di Minno, G. (1997). Factor V Leiden, C> T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thrombosis and haemostasis, 77(6), 1052-1054.3) (The title for this one is unfortunate, it is a randomized, controlled clinical study which is the gold standard, and it found the reduced B vitamins to work to alleviate symptoms of major depression as well as homocystine levels. 4) Sontag, J.-M., Wasek, B., Taleski, G., Smith, J., Arning, E., Sontag, E., & Bottiglieri, T. (2014). Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice. Frontiers in Aging Neuroscience, 6, 214. http://doi.org/10.3389/fnagi.2014.00214There is your taste!  There is also research showing lack of/poor sperm count in males with homozygous A1298C variant of MTHFR, higher risks of pre-eclampsia in pregnant women, etc., etc.,  At this point, I'm surprised that routine screening has not yet become a standard of care.  I hope that the variation of research articles here has helped you to understand why a more precise question is needed for a direct answer.  No single study will do it (and never does).  How about 2 decades of research?  :)

**Q: Ingredients?**
A: There seems to be some confusion about the difference between Methyl-Guard and Methyl-Guard PLUS, which costs twice as much as the regular Methyl-Guard listed on this page.Jana B.'s answers above seem to list the ingredients of the plus version, although the amounts appear to match that of the regular version. (?)This version does NOT have Riboflavin (B2) (Riboflavin 5'-Phosphate Sodium). In addition to B2, the plus version also claims to have more of all of the ingredients listed below.I have never purchased MG-Plus but I have a bottle of the regular Methyl-Guard in front of me.Here are the ingredients as listed:3 capsules contain:Vitamin B6 (as Pyridoxal 5'-Phosphate)   20.4 mg   1,020% DVFolate (as L-5 Methyltetrahydrofolate from L-5 Methyltetrahydrofolic Acid, Glucosamine Salt)   1.2 mg   300% DVVitamin B12 (as Methylcobalamin)   1.2 mg   20,000% DVBetaine Anhydrous (Trimethylglycine)   1.8 g   *DV not establishedOther Ingredients:Hypromellose (derived from cellulose) capsuleCalciumCitrateLaurate  (sic)Silicon DioxideSuggested Use: Take 3 capsules two times daily or as recommended by your health-care practitioner. (Personally, I only take 3 a day, not 6)

**Q: This states 180 capsules???**
A: Thorne Research - Methyl-Guard comes in a 180 capsule sized bottle.

**Q: What is the difference between the old label and the new label?**
A: Also some of the amounts are different. 
Old methyl guard:
Three Capsules Contain:
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg.
Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE
Vitamin B12 (as Methylcobalamin) 1.2 mg.
Betaine Anhydrous (Trimethylglycine) 1.8 g.

New Methyl guard Plus:
Three Capsules Contain:
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg
Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg
Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE
Vitamin B12 (as Methylcobalamin) 3 mg
Betaine Anhydrous (Trimethylglycine) 1.8 g 

This is from the thorne research website.
I love the old one (helps with depression) but the plus gives me a migraine.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Review
*by C***Y on 11 September 2025*

Excellent product for MTHFR genetic disorder

### ⭐⭐⭐⭐⭐ Review
*by J***N on 12 October 2025*

High quality B complex! Helpful for MTHFR gene mutation. I have been using them for about six months now and notice a huge difference in my cycle regularity, as it has very high amounts of B6 and a methylated form, I’m convinced is due to this product. My menstrual cramps have all but almost completely disappeared, which is absolutely amazing considering I have struggled with that since my teens could not recommend this more, especially for women struggling with similar issues.

### ⭐⭐⭐⭐⭐ Review
*by A***L on 4 August 2025*

I tell people that this is the first time I have ever felt a vitamin that I took. I have taken other B12 supplements in the past but this is the first one to significantly improve my B12 labs. It may seem expensive but I only take one a day so a bottle lasts me 6 months.

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*Product available on Desertcart Kuwait*
*Store origin: KW*
*Last updated: 2026-01-26*