FRONTLINE Plus Flea & Tick Spot Treatment for Large Breed Dogs 45-88 lbs. (Purple) Count of 3

After trying at least four different flea treatments that barely made a dent, I'm so relieved to have found these drops. They actually work - and work fast. We have two dogs who love being outside, and fleas have been an ongoing battle, especially during the warmer months. Within 24 hours of applying these drops, I noticed a huge difference. The scratching stopped, and when I checked them over, the fleas were gone. It's been several weeks now and still no sign of them coming back. Application is easy - just part the fur at the back of the neck and squeeze the tube. My dogs don't seem bothered by it at all, and it dries quickly so they can go about their day. The protection lasts the full month as advertised, which is more than I can say for some of the other brands we've tried. I've set up a subscription so I never run out because I'm not going back to the constant scratching and discomfort my pups were dealing with before. If you've been struggling to find an effective flea treatment, I highly recommend giving these a try. They've been a game-changer for us. Worth every penny for the peace of mind and happy, comfortable dogs!

This works very well on my 10 year old Golden Retriever. He is a “tick magnet” and when this medication is applied, the ticks will not embed on him. He never has a flea problem so I can’t speak to whether it works for fleas. It does not cause any skin irritation and has no odor. It seems to last the full month before ticks become a problem again.

This is hands-down the best flea and tick preventative made. I've tried others, such as Revolution, and would end up having to pick literally 20-50 attached ticks off my dog every time we went hiking and that was pretty much every day. Then they'd get in the house and be crawling on bedsheets and even across the keyboard of the computer - total nightmare. Since using Frontline, I rarely find any. Once in a while I'll find one or maybe two, but they're crawling on top of her fur and never attached. Since using Frontline, I haven't once found an attached tick on my dog nor my mom and dad's dog who is also treated with Frontline. They have had the same experience with their dog - the other brands just plain don't work - at least not for ticks, which is the main issues that we deal with, being that we live in the mountains and hike with the dogs almost ever day. Frontline works. Period. My only caveat is that you can't use this for people, which tells me that it's pretty toxic and that's why I'm giving it 4 stars instead of 5. It's pretty nasty stuff, you're supposed to avoid getting in on your skin and wash your hands immediately afterwards. If it's that toxic to humans, how safe can it be for our dogs? I really don't like the idea of putting something that's too toxic for humans on my dog and neither do my mom and dad. If we lived in the city and/or ticks weren't such an issue, we wouldn't use it. However, because of where we live and our lifestyle, the risks of tick-borne diseases outweigh the risks of the toxicity of the medicine. It's worth it for us. Decide for yourself if it's worth it for you.

Allow me to caveat this review by saying out of 700 plus reviews this is the most difficult to write as I despise having to use pesticides on our dogs. That said, we live in Tick and Flea central, surrounded by deep woods and our bulldogs are in every sense of the word family and we do whatever we must to protect them. That said if you're reading these reviews your dog or dogs are your heart too and using these products is a difficult choice to make, but it's one we have to make. On that note, it's my hope the following information has some value for you. Frontline was first put into clinical trials in 1985 shortly after the discovery of it's active ingredient Fipronil. To it's credit Frontline has maintained the safest albeit not the most effective treatment for fleas and ticks. However, the more effective products pose a significantly greater risk to your dog. It's a slippery slope, but in evaluating what's best for your dog by providing the highest level protection with the lowest risk Frontline and FrontLine Plus are in my opinion your best bet. Most tick and flea products contain Permethrin which may also be listed as Lyclear or Nix as the active ingredient. Permethrin is a lethal neurotoxin that flows through the dogs circulatory system and flushes into every major organ - including the brain where it can do dire damage. Thousands of dogs die every year from Permethrin. Although the FDA has mandated a minimal use not to exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price. What makes Permethrin so dangerous is that it can't distinguish between insects and mammals which of course includes human beings. It's been known to be lethal to cats since the 1970's. In fact it's so deadly to cats that even a slight transfer from dog to cat can result in seizures, brain damage and death. Permethrin is volatile as well - meaning it's airborne properties pose a threat to all who breath it in - humans included. Frontline on the other hand uses Fipronil. Fipronil is an insecticide. Like any chemical of this nature it can be lethal at too high of a dose. However studies including those from the Department of Environmental Conservation have determined time and time again that as long as the amount of Fipronil is at the correct dose for the weight and size of your dog toxicity is far easier to avoid and the product much safer for your dog. Unlike Premethrin, Fipronil is absorbed into the hair follicles and oil glands only. It is not absorbed into the dogs system nor is it volatile so you and your beloved pets and children can breath easy. The second active ingredient in FrontLine Plus is Methoprene which is a long existing and time proven IGR (insect growth regulator) it's distributed exactly like Fipronil but only acts on flea and tick eggs and Larvae - this is important because it kills these vermin at the start of a new life cycle. What is more, the diseases that ticks carry now are infinitely more serious than the dreaded Lime disease - which for decades was the only concern. Competitors to Frontline (and some Vets selling other products) claim that fleas and ticks have become resistant to Frontline - However these pests have become resistant to some degree to all pesticides and no independent research exists to confirm this claim. I can assure you I've researched this in the greatest depth. The bottom line is this - all of these products pose a risk. The wise choice is to minimize that risk in your effort to protect your best friend from the diseases these vermin carry. Again, these diseases can be infinitely more lethal than the ingredients of the protection. To that end your safest and most effective choice is Frontline or Frontline Plus. In the event your pet has a bad reaction to Frontline products these are the symptoms you would see: * Restlessness * Itching * Vomiting * Difficulty Breathing * Lethargy Should these symptoms occur, of course take your pet to your Veterinarian or emergency clinic immediately. It should be a comfort to know that unlike the toxic ingredients in most other flea and tick control products severe reactions to both Fipronil and Methoprene are rare.

Reliable flea & tick protection I’ve been using this flea and tick treatment for my dog, and it’s worked really well. It’s easy to apply, and I like that it provides long-lasting protection without needing to constantly reapply. I’ve noticed a big difference—no fleas, no ticks, and my dog hasn’t had any issues or reactions to it. It gives me peace of mind, especially during the warmer months when pests are the worst. Definitely a dependable option if you’re looking to keep your dog protected!

Buy this for our pup usually when they have a sale. Been using it for 11 years on him and no issues with either fleas or ticks here in IL & FL. Need to watch when they have it on sale, in either case it's not cheap!

My 65 pound lab mix loves to go for hikes in the woods every week, but in central PA our wooded areas have a massive tick problem. I bought the Frontline Plus Flea and Tick Control liquid treatment because it has been recommended to me before, including by my vet. The product packaging also claims it will “kill 100% of adult fleas and 100% of all ticks within 48 hours.” It also claims to be waterproof for 30 days, and to “kill all eggs left on the dog’s coat.” After applying the capsule to our dog’s back, we took her on the trails the following week and after checking her right after, we didn’t find any ticks. However, two days later she did manage to scratch a tick off of her and fling it onto the coffee table! The tick was full, like a berry, and utterly disgusting, but the product worked. The tick was dead, as promised. It should be made known that although the tick was dead, and so it was unable (supposedly) to lay eggs on our dog (typically a tick will lay 50 eggs a day on your dog, I read, while Frontline claims to kill ticks within hours before this can happen), ticks can obviously still bite your dog with this product on them, which can still effectively expose your dog to Lyme disease. This bothers me, since the idea behind applying it in the first place was that we don’t want ticks biting her at all so she can avoid Lymes altogether. The product lost some points with me here. The company, Merial, which manufactures Frontline, is a global company responsible for producing vaccines and medications for farm animals as well as pets. They seem to have a reputable track record, with 5 manufacturing sites in the United States as well as other countries. According to my research, and what is posted on the Merial website, Frontline Plus uses two major chemicals to achieve results of killing fleas and ticks. Both of the chemicals, S-Methoprene and Fipronil are harmless to mammals. According to one report I read online, however, about 5% of the fipronil does get absorbed into the dog’s bloodstream, which can metabolate into a different compound which can be up to 20% more harmful to your dog than it is to the insects. The website where I found that information, Dogs Naturally Magazine, seems a bit biased, though, in its interests. Further research showed that around 80 percent of the contents of Frontline Plus are not chemicals that fight pests, they are ethanol, glycol ether, and otherwise “inactive” ingredients. Since these “other” ingredients are inert, Merial doesn’t have to disclose much about them. I didn’t notice any weird side effects with my dog after using Frontline, but part of me still wonders if it’s the safest thing for her, since the company didn’t list the other ingredients in the product. It’s a bit off-putting. After doing some research, it does appear vets have conflicting ideas about Frontline use. Some believe it is linked to major illness that can potentially be linked to a dog’s death, while others claim there is nothing to be concerned about. Many respond to the rumors that Frontline is not healthy for dogs by acknowledging that many people apply the product incorrectly to their dog, resulting in pets having a reaction. Also, you’re not supposed to put the product onto raw skin areas or open wounds on your pet, or feed it to your pet, as the box also warns. The consensus among most veterinarians, and myself, is that while there are more natural ways of protecting your dog against ticks (some people suggest neem oil as a good alternative - whatever that is!), using more natural methods may result in your dog getting more ticks, which may then lead to higher risks of contracting tick-borne illness. In a place where the tick problem is so rampant, like where we live, I’d rather not take my chances. Not using a chemical prevention method is a tradeoff many pet owners feel is not worth the risk. Overall, the product did what it said it was going to do, and for that it gets 5 stars. But because I don’t have a clear idea of what “other ingredients” are (the company does not disclose them on the packaging), and because the product didn’t kill a tick before it bit my dog, I give it an average of 3 stars. My expectations were higher than what the product delivered. Although, this was my pet’s first time using Frontline, so I’m wondering if more consistent treatment will lead to better results.

Seems to work, witch is good for my dog.

It was very helpful I managed to get control of the continue scratching on her back

Very excellent and high quality

It works

My dog got extremely ill for 3 days afterwards . Seller doesn’t allow returns!