Will the penn battle ii 4000 reel fit on this rod?

yes it will, just about any spinning reel will

Is the hole in the tip guide large enough to pass a double-uni knot (6# mono leader tied to 8# braided line)?

I believe it is with room to spare. For the sizes of line you were using, and presuming you are using line That is of a diameter typical of today’s lines you should have no problem whatsoever. By way of example I Use an exaggerated number of wraps of a uniknot, Which would be considerably bigger than the double uni you are suggesting with 20 pound test flyfishing back line as bobber stops. And they go through the tip guide just fine

Can I use the Shimano Baitrunner 6000 on the medium heavy fast 2 piece?

Can you? Sure. Should you? Probably not. That really depends on what you plan to do. Are you putting out live bait and using the baitrunner feature? If so, sure, it would work (although that size reel is overkill and won't be a good weight balance).

Brand	Cadence
Material	Stainless Steel
Color	Black
Number of Pieces	1
Fishing Technique	Spinning
Item Weight	1.7 Pounds
Rod Length	5.6 Feet
Action	Fast
Line Weight	10 - 20 pounds
Grip Type	Split
Tension Level	High
Handle Material	Cork
Fishing Rod Power	Ultra Light
Product Dimensions	37.8"L x 2.36"W
Manufacturer	Cadence
Item Package Dimensions L x W x H	38.25 x 3 x 3 inches
Package Weight	0.77 Kilograms
Item Dimensions LxWxH	2.36 x 2.36 x 37.8 inches
Brand Name	Cadence
Style	5'6"\|anti Snapped\|ultralight\|moderate Fast\|2 Piece
Target Species	Bass, Flounder, Redfish, Walleye

Essence 2025 Compact Design Spinning Rod 5.6FT | 24-Ton Graphite Lightweight | Stainless Steel SIC Guides | Freshwater & Saltwater | High Sensitivity

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